Frailty and vulnerability as predictors of radiotoxicity in older adults: A longitudinal study in Peru. / Fragilidad y vulnerabilidad como predictores de radiotoxicidad en adultos mayores: un estudio longitudinal en Perú.
Med Clin (Barc)
; 149(8): 325-330, 2017 Oct 23.
Article
em En, Es
| MEDLINE
| ID: mdl-28400051
ABSTRACT
BACKGROUND AND OBJECTIVE:
To assess the association between frailty/vulnerability and the development of radiotoxicity in older adults at a hospital in Peru. MATERIAL ANDMETHODS:
Cohort study that included patients with cancer with medical recommendation of radiotherapy, who attended the outpatient department of geriatrics at Naval Medical Center (Lima, Peru) between 2013 and 2015. Before receiving radiation therapy sessions, we measured frailty using Fried phenotype, and vulnerability using VES-13 and G-8 scales. During radiotherapy, we determined the development of radiotoxicity. ROC curves and crude/adjusted Cox regression models were prepared to evaluate the association between the frailty/vulnerability scales and the development of radiotoxicity respectively.RESULTS:
From a total of 181 patients (mean age 78.1 years, all males), 33 (18.2%) developed some type of radiotoxicity. The appearance of radiotoxicity was higher in patients with frailty or vulnerability compared with those without these conditions, according to the usual cutoff points of Fried phenotype (10.9% versus 41.9%), VES-13 (5.0% versus 63.4%) and G-8 (5.6% versus 67.6%). The area under the curve was 0.61 (0.55-0.65) for the Fried phenotype, 0.79 (0.69-0.86) for the VES-13, and 0.86 (0.58-0.89) for the G-8.CONCLUSIONS:
We found an association between frailty/vulnerability and the development of radiotoxicity. The G-8 and the VES-13 scales had a better area under the curve than Fried phenotype, suggesting that those could be useful tools when deciding the dose of radiotherapy in geriatric patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões por Radiação
/
Radioterapia
/
Avaliação Geriátrica
/
Idoso Fragilizado
/
Fragilidade
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Peru
Idioma:
En
/
Es
Ano de publicação:
2017
Tipo de documento:
Article