Copper-catalysed enantioselective Michael addition of malonic esters to ß-trifluoromethyl-α,ß-unsaturated imines.
Org Biomol Chem
; 15(18): 3849-3853, 2017 May 10.
Article
em En
| MEDLINE
| ID: mdl-28406259
ABSTRACT
Copper triflate-BOX complexes catalyse the enantioselective conjugate addition of methyl malonate to ß-trifluoromethyl-α,ß-unsaturated imines to give the corresponding enamines bearing a trifluoromethylated stereogenic centre with good yields, and diastereo- and enantioselectivities. The usefulness of the method has been shown with the synthesis of optically active ß-trifluoromethyl δ-amino esters and optically active trifluoromethyl piperidones.
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01-internacional
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MEDLINE
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En
Ano de publicação:
2017
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Article