Excitatory neurons sculpt GABAergic neuronal connectivity in the C. elegans motor circuit.
Development
; 144(10): 1807-1819, 2017 05 15.
Article
em En
| MEDLINE
| ID: mdl-28420711
ABSTRACT
Establishing and maintaining the appropriate number of GABA synapses is key for balancing excitation and inhibition in the nervous system, though we have only a limited understanding of the mechanisms controlling GABA circuit connectivity. Here, we show that disrupting cholinergic innervation of GABAergic neurons in the C. elegans motor circuit alters GABAergic neuron synaptic connectivity. These changes are accompanied by reduced frequency and increased amplitude of GABAergic synaptic events. Acute genetic disruption in early development, during the integration of post-embryonic-born GABAergic neurons into the circuit, produces irreversible effects on GABAergic synaptic connectivity that mimic those produced by chronic manipulations. In contrast, acute genetic disruption of cholinergic signaling in the adult circuit does not reproduce these effects. Our findings reveal that GABAergic signaling is regulated by cholinergic neuronal activity, probably through distinct mechanisms in the developing and mature nervous system.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
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Caenorhabditis elegans
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Transmissão Sináptica
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Neurônios Colinérgicos
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Neurônios GABAérgicos
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Neurônios Motores
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Rede Nervosa
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article