Hepatic sinusoidal obstruction syndrome during maintenance therapy of childhood acute lymphoblastic leukemia is associated with continuous asparaginase therapy and mercaptopurine metabolites.

Toksvang, Linea Natalie; De Pietri, Silvia; Nielsen, Stine N; Nersting, Jacob; Albertsen, Birgitte K; Wehner, Peder S; Rosthøj, Steen; Lähteenmäki, Päivi M; Nilsson, Daniel; Nystad, Tove A; Grell, Kathrine; Frandsen, Thomas L; Schmiegelow, Kjeld

Toksvang, Linea Natalie; De Pietri, Silvia; Nielsen, Stine N; Nersting, Jacob; Albertsen, Birgitte K; Wehner, Peder S; Rosthøj, Steen; Lähteenmäki, Päivi M; Nilsson, Daniel; Nystad, Tove A; Grell, Kathrine; Frandsen, Thomas L; Schmiegelow, Kjeld.

Afiliação

Toksvang LN; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
De Pietri S; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
Nielsen SN; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
Nersting J; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
Albertsen BK; Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.
Wehner PS; Department of Pediatric Hematology and Oncology, H. C. Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
Rosthøj S; Department of Pediatrics, Aalborg University Hospital, Aalborg, Denmark.
Lähteenmäki PM; Department of Pediatric and Adolescent Medicine, Turku University Hospital, Turku, Finland.
Nilsson D; Department of Pediatrics, Astrid Lindgrens Hospital, Stockholm, Sweden.
Nystad TA; Department of Pediatrics, University Hospital North Norway, Tromsø, Norway.
Grell K; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
Frandsen TL; Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Schmiegelow K; Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.

Pediatr Blood Cancer ; 64(9)2017 Sep.

Article em En | MEDLINE | ID: mdl-28423235

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos; Hepatopatia Veno-Oclusiva/induzido quimicamente; Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico; Adolescente; Asparaginase/administração & dosagem; Asparaginase/efeitos adversos; Criança; Pré-Escolar; Interações Medicamentosas; Feminino; Humanos; Lactente; Estimativa de Kaplan-Meier; Quimioterapia de Manutenção; Masculino; Mercaptopurina/administração & dosagem; Mercaptopurina/efeitos adversos; Mercaptopurina/metabolismo; Metotrexato/administração & dosagem; Metotrexato/efeitos adversos; Polietilenoglicóis/administração & dosagem; Polietilenoglicóis/efeitos adversos; Modelos de Riscos Proporcionais

Palavras-chave

acute lymphoblastic leukemia; asparaginase; liver toxicity; maintenance therapy; sinusoidal obstruction syndrome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatopatia Veno-Oclusiva / Protocolos de Quimioterapia Combinada Antineoplásica / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudo: Clinical_trials / Guideline / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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