Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape.
Immunity
; 46(4): 532-548, 2017 04 18.
Article
em En
| MEDLINE
| ID: mdl-28423335
ABSTRACT
The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunidade Adaptativa
/
Microbioma Gastrointestinal
/
Sistema Imunitário
/
Mucosa Intestinal
/
Intestinos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article