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Zinc Absorption from Milk Is Affected by Dilution but Not by Thermal Processing, and Milk Enhances Absorption of Zinc from High-Phytate Rice in Young Dutch Women.
Talsma, Elise F; Moretti, Diego; Ly, Sou Chheng; Dekkers, Renske; van den Heuvel, Ellen Ghm; Fitri, Aditia; Boelsma, Esther; Stomph, Tjeerd Jan; Zeder, Christophe; Melse-Boonstra, Alida.
Afiliação
  • Talsma EF; Division of Human Nutrition.
  • Moretti D; HarvestPlus, International Center for Tropical Agriculture (CIAT), Cali, Colombia.
  • Ly SC; Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland; and.
  • Dekkers R; Division of Human Nutrition.
  • van den Heuvel EG; Friesland-Campina, Amersfoort, Netherlands.
  • Fitri A; Friesland-Campina, Amersfoort, Netherlands.
  • Boelsma E; Friesland-Campina, Amersfoort, Netherlands.
  • Stomph TJ; Wageningen Food and Biobased Research, and.
  • Zeder C; Center for Crop Systems Analysis, Wageningen University and Research, Wageningen, Netherlands.
  • Melse-Boonstra A; Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland; and.
J Nutr ; 147(6): 1086-1093, 2017 06.
Article em En | MEDLINE | ID: mdl-28424261
Background: Milk has been suggested to increase zinc absorption. The effect of processing and the ability of milk to enhance zinc absorption from other foods has not been measured directly in humans.Objective: We aimed to assess zinc absorption from 1) milk undergoing various processing and preparatory steps and 2) from intrinsically labeled high-phytate rice consumed with milk or water.Methods: Two randomized crossover studies were conducted in healthy young women [age:18-25 y; body mass index (in kg/m2): 20-25]: 1) a milk study (n = 19) comparing the consumption of 800 mL full-fat ultra-high temperature (UHT) milk [heat-treated milk (HTM)], full-fat UHT milk diluted 1:1 with water [heat-treated milk and water (MW)], water, or unprocessed (raw) milk (UM), each extrinsically labeled with 67Zn, and 2) a rice study (n = 18) comparing the consumption of 90 g intrinsically 67Zn-labeled rice with 600 mL of water [rice and water (RW)] or full-fat UHT milk [rice and milk (RM)]. The fractional absorption of zinc (FAZ) was measured with the double-isotope tracer ratio method. In vitro, we assessed zinc extraction from rice blended into water, UM, or HTM with or without phytate.Results: FAZ from HTM was 25.5% (95% CI: 21.6%, 29.4%) and was not different from UM (27.8%; 95% CI: 24.2%, 31.4%). FAZ from water was higher (72.3%; 95% CI: 68.7%, 75.9%), whereas FAZ from MW was lower (19.7%; 95% CI: 17.5%, 21.9%) than HTM and UM (both P < 0.01). FAZ from RM (20.7%; 95% CI: 18.8%, 22.7%) was significantly higher than from RW (12.8%; 95% CI: 10.8%, 14.6%; P < 0.01). In vitro, HTM and UM showed several orders of magnitude higher extraction of zinc from rice with HTM than from rice with water at various phytate concentrations.Conclusions: Milk enhanced human FAZ from high-phytate rice by 62% compared with water. Diluting milk with water decreases its absorption-enhancing proprieties, whereas UHT processing does not. This trial was registered at the Dutch trial registry as NTR4267 (http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4267).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Fítico / Oryza / Zinco / Água / Leite / Temperatura Alta / Absorção Intestinal Tipo de estudo: Clinical_trials Limite: Adult / Animals / Female / Humans País/Região como assunto: Europa Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Fítico / Oryza / Zinco / Água / Leite / Temperatura Alta / Absorção Intestinal Tipo de estudo: Clinical_trials Limite: Adult / Animals / Female / Humans País/Região como assunto: Europa Idioma: En Ano de publicação: 2017 Tipo de documento: Article