MiR-198 enhances temozolomide sensitivity in glioblastoma by targeting MGMT.

Nie, Er; Jin, Xin; Wu, Weining; Yu, Tianfu; Zhou, Xu; Shi, Zhumei; Zhang, Junxia; Liu, Ning; You, Yongping

Nie, Er; Jin, Xin; Wu, Weining; Yu, Tianfu; Zhou, Xu; Shi, Zhumei; Zhang, Junxia; Liu, Ning; You, Yongping.

Afiliação

Nie E; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Jin X; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Wu W; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Yu T; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Zhou X; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Shi Z; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Zhang J; State Key Lab of Reproductive Medicine, Department of Pathology, Collaborative Innovation Center for Cancer Personalized Medicine, Cancer Center, Nanjing Medical University, Nanjing, 210029, China.
Liu N; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
You Y; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

J Neurooncol ; 133(1): 59-68, 2017 05.

Article em En | MEDLINE | ID: mdl-28425046

Assuntos

Antineoplásicos Alquilantes/uso terapêutico; Neoplasias Encefálicas/tratamento farmacológico; Metilases de Modificação do DNA/metabolismo; Enzimas Reparadoras do DNA/metabolismo; Dacarbazina/análogos & derivados; Glioblastoma/tratamento farmacológico; MicroRNAs/metabolismo; Proteínas Supressoras de Tumor/metabolismo; Adulto; Idoso; Animais; Antineoplásicos Alquilantes/farmacologia; Astrócitos/efeitos dos fármacos; Astrócitos/metabolismo; Neoplasias Encefálicas/metabolismo; Linhagem Celular Tumoral; Metilases de Modificação do DNA/genética; Enzimas Reparadoras do DNA/genética; Dacarbazina/farmacologia; Dacarbazina/uso terapêutico; Resistencia a Medicamentos Antineoplásicos/fisiologia; Feminino; Glioblastoma/metabolismo; Células Endoteliais da Veia Umbilical Humana; Humanos; Masculino; Camundongos Endogâmicos NOD; Camundongos SCID; Pessoa de Meia-Idade; Transplante de Neoplasias; RNA Mensageiro/metabolismo; Temozolomida; Proteínas Supressoras de Tumor/genética; Adulto Jovem

Palavras-chave

Glioblastoma; MGMT; Temozolomide resistance; miR-198

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Metilases de Modificação do DNA / Glioblastoma / Antineoplásicos Alquilantes / Proteínas Supressoras de Tumor / Dacarbazina / MicroRNAs / Enzimas Reparadoras do DNA Tipo de estudo: Diagnostic_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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