Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.

Davies, Anna M; Allan, Elizabeth G; Keeble, Anthony H; Delgado, Jean; Cossins, Benjamin P; Mitropoulou, Alkistis N; Pang, Marie O Y; Ceska, Tom; Beavil, Andrew J; Craggs, Graham; Westwood, Marta; Henry, Alistair J; McDonnell, James M; Sutton, Brian J

Davies, Anna M; Allan, Elizabeth G; Keeble, Anthony H; Delgado, Jean; Cossins, Benjamin P; Mitropoulou, Alkistis N; Pang, Marie O Y; Ceska, Tom; Beavil, Andrew J; Craggs, Graham; Westwood, Marta; Henry, Alistair J; McDonnell, James M; Sutton, Brian J.

Afiliação

Davies AM; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.
Allan EG; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and.
Keeble AH; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.
Delgado J; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and.
Cossins BP; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.
Mitropoulou AN; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and.
Pang MOY; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom.
Ceska T; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom.
Beavil AJ; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.
Craggs G; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and.
Westwood M; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.
Henry AJ; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and.
McDonnell JM; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom.
Sutton BJ; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.

J Biol Chem ; 292(24): 9975-9987, 2017 06 16.

Article em En | MEDLINE | ID: mdl-28438838

Assuntos

Antiasmáticos/farmacologia; Imunoglobulina E/metabolismo; Modelos Moleculares; Omalizumab/farmacologia; Receptores de IgE/antagonistas & inibidores; Sítio Alostérico; Substituição de Aminoácidos; Cristalografia por Raios X; Transferência Ressonante de Energia de Fluorescência; Humanos; Imunoglobulina E/química; Imunoglobulina E/genética; Fragmentos Fab das Imunoglobulinas/química; Fragmentos Fab das Imunoglobulinas/genética; Fragmentos Fab das Imunoglobulinas/metabolismo; Fragmentos Fab das Imunoglobulinas/farmacologia; Fragmentos Fc das Imunoglobulinas/química; Fragmentos Fc das Imunoglobulinas/genética; Fragmentos Fc das Imunoglobulinas/metabolismo; Fragmentos Fc das Imunoglobulinas/farmacologia; Omalizumab/química; Omalizumab/genética; Omalizumab/metabolismo; Maleabilidade; Mutação Puntual; Conformação Proteica; Domínios e Motivos de Interação entre Proteínas; Redobramento de Proteína; Receptores de IgE/química; Receptores de IgE/metabolismo; Proteínas Recombinantes de Fusão/química; Proteínas Recombinantes de Fusão/metabolismo; Proteínas Recombinantes de Fusão/farmacologia; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Proteínas Recombinantes/farmacologia; Solubilidade; Ressonância de Plasmônio de Superfície

Palavras-chave

X-ray crystallography; allergy; allosteric regulation; antibody; immunoglobulin E (IgE); omalizumab

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina E / Modelos Moleculares / Receptores de IgE / Antiasmáticos / Omalizumab Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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