Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cells.

Byun, Hyo Joo; Darvin, Pramod; Kang, Dong Young; Sp, Nipin; Joung, Youn Hee; Park, Jong Hwan; Kim, Sun Jin; Yang, Young Mok

Byun, Hyo Joo; Darvin, Pramod; Kang, Dong Young; Sp, Nipin; Joung, Youn Hee; Park, Jong Hwan; Kim, Sun Jin; Yang, Young Mok.

Afiliação

Byun HJ; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju 27478, Republic of Korea.
Darvin P; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju 27478, Republic of Korea.
Kang DY; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju 27478, Republic of Korea.
Sp N; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju 27478, Republic of Korea.
Joung YH; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju 27478, Republic of Korea.
Park JH; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju 27478, Republic of Korea.
Kim SJ; Trinity Court, Cardiff CF24 0AA, Wales, UK.
Yang YM; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju 27478, Republic of Korea.

Oncol Rep ; 37(6): 3270-3278, 2017 Jun.

Article em En | MEDLINE | ID: mdl-28440514

Assuntos

Janus Quinase 2/genética; Metaloproteinase 2 da Matriz/genética; Fator de Transcrição STAT3/genética; Silimarina/administração & dosagem; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Feminino; Humanos; Invasividade Neoplásica/genética; Fosforilação; Transdução de Sinais/efeitos dos fármacos; Silibina; Neoplasias de Mama Triplo Negativas/genética; Neoplasias de Mama Triplo Negativas/patologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Silimarina / Metaloproteinase 2 da Matriz / Fator de Transcrição STAT3 / Janus Quinase 2 / Neoplasias de Mama Triplo Negativas Limite: Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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