Mitochondrial LON protease-dependent degradation of cytochrome c oxidase subunits under hypoxia and myocardial ischemia.

Sepuri, Naresh B V; Angireddy, Rajesh; Srinivasan, Satish; Guha, Manti; Spear, Joseph; Lu, Bin; Anandatheerthavarada, Hindupur K; Suzuki, Carolyn K; Avadhani, Narayan G

Sepuri, Naresh B V; Angireddy, Rajesh; Srinivasan, Satish; Guha, Manti; Spear, Joseph; Lu, Bin; Anandatheerthavarada, Hindupur K; Suzuki, Carolyn K; Avadhani, Narayan G.

Afiliação

Sepuri NBV; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6009, USA.
Angireddy R; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6009, USA.
Srinivasan S; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6009, USA.
Guha M; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6009, USA.
Spear J; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6009, USA.
Lu B; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers The State University, New Jersey Medical School, 225 Warren Street, Newark, NJ 17103-3535, USA.
Anandatheerthavarada HK; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6009, USA.
Suzuki CK; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers The State University, New Jersey Medical School, 225 Warren Street, Newark, NJ 17103-3535, USA.
Avadhani NG; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6009, USA. Electronic address: narayan@vet.upenn.edu.

Biochim Biophys Acta Bioenerg ; 1858(7): 519-528, 2017 Jul.

Article em En | MEDLINE | ID: mdl-28442264

Assuntos

Proteases Dependentes de ATP/metabolismo; Hipóxia Celular/fisiologia; Complexo IV da Cadeia de Transporte de Elétrons/metabolismo; Mitocôndrias Cardíacas/enzimologia; Proteínas Mitocondriais/metabolismo; Isquemia Miocárdica/enzimologia; Proteases Dependentes de ATP/química; Proteases Dependentes de ATP/genética; Animais; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Humanos; Masculino; Camundongos; Proteínas Mitocondriais/química; Proteínas Mitocondriais/genética; Modelos Moleculares; Fosforilação; Conformação Proteica; Processamento de Proteína Pós-Traducional; Subunidades Proteicas; Células RAW 264.7; Interferência de RNA; RNA Interferente Pequeno/genética; Coelhos; Proteínas Recombinantes/metabolismo

Palavras-chave

3D modeling; CcO subunits; Heart ischemia; Hypoxia; Mitochondrial LON; PKA dependent phosphorylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipóxia Celular / Isquemia Miocárdica / Complexo IV da Cadeia de Transporte de Elétrons / Proteínas Mitocondriais / Proteases Dependentes de ATP / Mitocôndrias Cardíacas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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