Your browser doesn't support javascript.
loading
Deferiprone for the treatment of transfusional iron overload in thalassemia.
Belmont, Ami; Kwiatkowski, Janet L.
Afiliação
  • Belmont A; a Alpert Medical School of Brown University , Providence , RI , USA.
  • Kwiatkowski JL; b Children's Hospital of Philadelphia, Division of Hematology and Perelman School of Medicine at the University of Pennsylvania, Department of Pediatrics , Philadelphia , PA , USA.
Expert Rev Hematol ; 10(6): 493-503, 2017 06.
Article em En | MEDLINE | ID: mdl-28448199
ABSTRACT

INTRODUCTION:

Transfusional iron overload can lead to hepatic fibrosis, arrhythmias and congestive heart failure and a number of endocrinopathies. Deferiprone is an oral iron chelator approved for use in the United States as a second line agent for the treatment of transfusional iron overload in patients with thalassemia. Areas covered This article will review the data regarding the efficacy of deferiprone for iron chelation and prevention and reversal of iron related complications, the drug's adverse effect profile, and the use of this drug in combination regimens. Expert commentary Extensive data support that deferiprone is particularly efficacious at cardiac iron removal and therefore, a chelator regimen that contains deferiprone is generally recommended when there is significant cardiac iron loading and/or in the setting of iron-related cardiac disease. The most concerning side effects of deferiprone are agranulocytosis and milder forms of neutropenia, which require appropriate monitoring and patient/provider education.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Talassemia / Transfusão de Eritrócitos / Sobrecarga de Ferro Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Talassemia / Transfusão de Eritrócitos / Sobrecarga de Ferro Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article