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Harnessing macrophage plasticity for tissue regeneration.
Smith, Tim D; Nagalla, Raji R; Chen, Esther Y; Liu, Wendy F.
Afiliação
  • Smith TD; Department of Biomedical Engineering, University of California, Irvine, United States; Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, United States.
  • Nagalla RR; Department of Biomedical Engineering, University of California, Irvine, United States; Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, United States.
  • Chen EY; Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, United States; Department of Chemical Engineering and Materials Science, University of California, Irvine, United States.
  • Liu WF; Department of Biomedical Engineering, University of California, Irvine, United States; Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, United States; Department of Chemical Engineering and Materials Science, University of California, Irvine, Unit
Adv Drug Deliv Rev ; 114: 193-205, 2017 05 15.
Article em En | MEDLINE | ID: mdl-28449872
ABSTRACT
Macrophages are versatile and plastic effector cells of the immune system, and contribute to diverse immune functions including pathogen or apoptotic cell removal, inflammatory activation and resolution, and tissue healing. Macrophages function as signaling regulators and amplifiers, and influencing their activity is a powerful approach for controlling inflammation or inducing a wound-healing response in regenerative medicine. This review discusses biomaterials-based approaches for altering macrophage activity, approaches for targeting drugs to macrophages, and approaches for delivering macrophages themselves as a therapeutic intervention.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Medicina Regenerativa / Macrófagos Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Medicina Regenerativa / Macrófagos Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article