Metalloriboswitches: RNA-based inorganic ion sensors that regulate genes.
J Biol Chem
; 292(23): 9441-9450, 2017 06 09.
Article
em En
| MEDLINE
| ID: mdl-28455443
ABSTRACT
Divalent ions fulfill essential cellular roles and are required for virulence by certain bacteria. Free intracellular Mg2+ can approach 5 mm, but at this level Mn2+, Ni2+, or Co2+ can be growth-inhibitory, and magnesium fluoride is toxic. To maintain ion homeostasis, many bacteria have evolved ion sensors embedded in the 5'-leader sequences of mRNAs encoding ion uptake or efflux channels. Here, we review current insights into these "metalloriboswitches," emphasizing ion-specific binding by structured RNA aptamers and associated conformational changes in downstream signal sequences. This riboswitch-effector interplay produces a layer of gene regulatory feedback that has elicited interest as an antibacterial target.
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Base de dados:
MEDLINE
Assunto principal:
Bactérias
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RNA Bacteriano
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Metais Pesados
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Riboswitch
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Conformação de Ácido Nucleico
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article