Surface functionalized magnetic nanoparticles shift cell behavior with on/off magnetic fields.
J Cell Physiol
; 233(2): 1168-1178, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-28464242
Magnetic nanoparticles (MNPs) are used as contrast agents and targeted drug delivery systems (TDDS) due to their favorable size, surface charge, and magnetic properties. Unfortunately, the toxicity associated with MNPs limits their biological applications. Surface functionalization of MNPs with selective polymers alters the surface chemistry to impart better biocompatibility. We report the preparation of surface functionalized MNPs using iron oxide NPs (MNPs), poly (lactic-co-glycolic acid) (PLGA), and sodium alginate via co-precipitation, emulsification, and electro-spraying, respectively. The NPs are in the nanosize range and negatively charged. Morphological and structural analyses affirm the surface functionalized nanostructure of the NPs. The surface functionalized MNPs are biocompatible, and demonstrate enhanced intracellular delivery under an applied magnetic field (H), which evinces the targeting ability of MNPs. After NP treatment, the physico-mechanical properties of fibroblasts are decided by the selective MNP uptake under "on" or "off" magnetic field conditions. We envision potential use of biocompatible surface functionalized MNP for intracellular-, targeted-DDS, imaging, and for investigating cellular mechanics.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Poliglicólico
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Materiais Biocompatíveis
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Ácido Láctico
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Reagentes de Ligações Cruzadas
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Alginatos
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Nanomedicina
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Nanopartículas de Magnetita
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Campos Magnéticos
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Magnetismo
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article