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Neurokinin A selectively inhibits water intake in the rat.
Perfumi, M; Polidori, C; Massi, M; de Caro, G.
Afiliação
  • Perfumi M; Institute of Pharmacology, Faculty of Pharmacy, University of Camerino, Italy.
Neuropharmacology ; 27(9): 909-14, 1988 Sep.
Article em En | MEDLINE | ID: mdl-2847071
The results of the present study show that the intracerebroventricular injection of neurokinin A elicited a selective antidipsogenic effect in the rat. Neurokinin A proved to be an extremely potent inhibitor of drinking elicited by subcutaneous administration of hypertonic NaCl, and produced also a statistically-significant inhibition of food-associated drinking. On the other hand, it did not affect drinking evoked by other dipsogenic determinants, such as water deprivation and intracerebroventricular injection of carbachol or of angiotensin II. Thus, neurokinin A shows a spectrum of antidipsogenic activity clearly different from that of substance P, the other mammalian tachykinin so far tested on drinking behaviour in the rat, which appears to be a non-selective antidipsogenic agent. The findings of the present study suggest that different tachykinins, endogenous to the brain of the rat, might subserve distinct roles in the control of drinking behaviour.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurocinina A / Ingestão de Líquidos Limite: Animals Idioma: En Ano de publicação: 1988 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurocinina A / Ingestão de Líquidos Limite: Animals Idioma: En Ano de publicação: 1988 Tipo de documento: Article