Upper esophageal sphincter abnormalities and high-resolution esophageal manometry findings in patients with laryngopharyngeal reflux.
Scand J Gastroenterol
; 52(8): 816-821, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28471304
ABSTRACT
BACKGROUND:
The association between laryngopharyngeal reflux (LPR) and abnormalities of upper esophageal sphincter (UES) and esophageal motility is not clearly known. High-resolution esophageal manometry (HREM) has allowed accurate measurement and evaluation of UES and esophageal function. GOALS To evaluate the UES function and esophageal motility using HREM in patients with LPR and compare them to patients with typical gastroesophageal reflux disease (GERD). STUDY All patients evaluated for GERD or LPR symptoms with esophageal function testing including HREM, ambulatory distal pH monitoring and upper endoscopy between 2006 and 2014 were retrospectively studied (n = 220). The study group (group A, n = 57) consisted of patients diagnosed with LPR after comprehensive evaluation. They were compared to patients who had typical GERD symptoms only (group B, n = 98) and patients with both GERD and LPR symptoms (group C, n = 65).RESULTS:
Abnormalities in UES pressures and relaxation were found in about one-third of patients in all groups. There were no significant differences between the groups. Group B had higher prevalence of abnormal esophageal motility compared to others (group A vs. B vs. C = 20.8% vs. 28% vs. 12.5%, p = .029). Group B patients also had higher prevalence of Barrett's esophagus compared to others (group A vs. B vs. C = 0% vs.12.2% vs. 4.6%, p = .01). Distal pH testing revealed no significant differences between the three groups.CONCLUSIONS:
Abnormal UES function was noted in one-third of patients with LPR or GERD. However, there were no abnormalities on esophageal function testing specific for LPR.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esôfago de Barrett
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Esfíncter Esofágico Superior
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Refluxo Laringofaríngeo
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Manometria
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article