Joining Forces: Bmi1 Inhibition and Cisplatin Curb Squamous Carcinogenesis.
Cell Stem Cell
; 20(5): 575-577, 2017 05 04.
Article
em En
| MEDLINE
| ID: mdl-28475877
ABSTRACT
Head and neck squamous cell carcinomas (HNSCCs) are refractory to therapeutic interventions. Chen et al. (2017) show that mouse and human HNSCCs and their metastases depend on Bmi1-expressing cancer stem cells and AP1 signaling and that simultaneously inhibiting Bmi1 or AP1, combined with Cisplatin, reduces tumor growth effectively in preclinical models.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
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Cisplatino
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Complexo Repressor Polycomb 1
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Neoplasias de Cabeça e Pescoço
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article