New gentle-wing high-shear granulator: impact of processing variables on granules and tablets characteristics of high-drug loading formulation using design of experiment approach.

Fayed, Mohamed H; Abdel-Rahman, Sayed I; Alanazi, Fars K; Ahmed, Mahrous O; Tawfeek, Hesham M; Al-Shdefat, Ramadan I

Fayed, Mohamed H; Abdel-Rahman, Sayed I; Alanazi, Fars K; Ahmed, Mahrous O; Tawfeek, Hesham M; Al-Shdefat, Ramadan I.

Afiliação

Fayed MH; a Department of Pharmaceutics, College of Pharmacy , Prince Sattam Bin Abdulaziz University , Al-kharj , Saudi Arabia.
Abdel-Rahman SI; b Department of Industrial Pharmacy, Faculty of Pharmacy , Assiut University , Assiut , Egypt.
Alanazi FK; c Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy , King Saud University , Riyadh , Saudi Arabia.
Ahmed MO; b Department of Industrial Pharmacy, Faculty of Pharmacy , Assiut University , Assiut , Egypt.
Tawfeek HM; b Department of Industrial Pharmacy, Faculty of Pharmacy , Assiut University , Assiut , Egypt.
Al-Shdefat RI; a Department of Pharmaceutics, College of Pharmacy , Prince Sattam Bin Abdulaziz University , Al-kharj , Saudi Arabia.

Drug Dev Ind Pharm ; 43(10): 1584-1600, 2017 Oct.

Article em En | MEDLINE | ID: mdl-28480773

Assuntos

Composição de Medicamentos/métodos; Povidona/química; Tecnologia Farmacêutica/métodos; Química Farmacêutica; Povidona/administração & dosagem; Estudos Prospectivos; Análise de Regressão; Solubilidade; Comprimidos

Palavras-chave

Acetaminophen; central composite; experimental design; high-shear granulation; quality-by-design; tableting

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Povidona / Tecnologia Farmacêutica / Composição de Medicamentos Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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