Proteasome as a New Target for Bio-Inspired Benzo[k,l]xanthene Lignans.
Chemistry
; 23(35): 8371-8374, 2017 Jun 22.
Article
em En
| MEDLINE
| ID: mdl-28485479
ABSTRACT
Mass spectrometry-based chemical proteomics is a powerful tool for the target discovery of small molecules. Here, the application of this approach is presented to define the target profile of bio-inspired synthetic benzo[k,l]xanthene lignans endowed with interesting biological properties. Proteasome has been identified as a new main interactor for this class of compounds. A combination of molecular docking with in vitro and in cell fluorescence assays gave insights on the molecular mechanism of the interaction, highlighting the tendency of these lignans to inhibit the proteasome.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Xantenos
/
Lignanas
/
Materiais Biomiméticos
/
Complexo de Endopeptidases do Proteassoma
/
Inibidores de Proteassoma
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article