Next-Generation Sequencing-based genomic profiling of brain metastases of primary ovarian cancer identifies high number of BRCA-mutations.

Balendran, S; Liebmann-Reindl, S; Berghoff, A S; Reischer, T; Popitsch, N; Geier, C B; Kenner, L; Birner, P; Streubel, B; Preusser, M

Balendran, S; Liebmann-Reindl, S; Berghoff, A S; Reischer, T; Popitsch, N; Geier, C B; Kenner, L; Birner, P; Streubel, B; Preusser, M.

Afiliação

Balendran S; Department of Pathology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Liebmann-Reindl S; Core Facility Genomics, Medical University of Vienna, Vienna, Austria.
Berghoff AS; Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Reischer T; Comprehensive Cancer Center, Central Nervous System Unit (CCC-CNS), Medical University of Vienna, Vienna, Austria.
Popitsch N; Neurology Clinic, Heidelberg University Medical Center and Neurooncology Program, National Center for Tumor Diseases Heidelberg, Heidelberg, Germany.
Geier CB; Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
Kenner L; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Birner P; Immunology Outpatient Clinic, Schwarzspanierstraße 15/1/9, Vienna, Austria.
Streubel B; Department of Pathology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Preusser M; Department of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria.

J Neurooncol ; 133(3): 469-476, 2017 Jul.

Article em En | MEDLINE | ID: mdl-28497333

Assuntos

Neoplasias Encefálicas/genética; Neoplasias Encefálicas/secundário; Mutação; Neoplasias Ovarianas/genética; Neoplasias Ovarianas/patologia; Adulto; Idoso; Proteínas Mutadas de Ataxia Telangiectasia/genética; Proteína BRCA1/genética; Proteína BRCA2/genética; Feminino; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Pessoa de Meia-Idade; Neoplasias Ovarianas/tratamento farmacológico; Estudos Retrospectivos; Proteína Supressora de Tumor p53/genética

Palavras-chave

ATM; BRCA1/2; Brain metastases; Next-Generation Sequencing; Ovarian cancer; TP53

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Neoplasias Encefálicas / Mutação Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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