BAG-1M co-activates BACE1 transcription through NF-&#954;B and accelerates Aß production and memory deficit in Alzheimer's disease mouse model.

Shi, Zhemin; Hong, Yuheng; Zhang, Kun; Wang, Jingzhao; Zheng, Lina; Zhang, Zhen; Hu, Zhimei; Han, Xiaohui; Han, Yawei; Chen, Ting; Yao, Qingbin; Cui, Hongmei; Hong, Wei

BAG-1M co-activates BACE1 transcription through NF-κB and accelerates Aß production and memory deficit in Alzheimer's disease mouse model.

Shi, Zhemin; Hong, Yuheng; Zhang, Kun; Wang, Jingzhao; Zheng, Lina; Zhang, Zhen; Hu, Zhimei; Han, Xiaohui; Han, Yawei; Chen, Ting; Yao, Qingbin; Cui, Hongmei; Hong, Wei.

Afiliação

Shi Z; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Hong Y; School of Medical Imaging, Tianjin Medical University, Tianjin 300203, China.
Zhang K; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Wang J; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Zheng L; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Zhang Z; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Hu Z; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Han X; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Han Y; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Chen T; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Yao Q; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Cui H; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Hong W; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. Electronic address: hongwei@tijmu.edu.cn.

Biochim Biophys Acta Mol Basis Dis ; 1863(9): 2398-2407, 2017 09.

Article em En | MEDLINE | ID: mdl-28502705

Assuntos

Doença de Alzheimer/metabolismo; Secretases da Proteína Precursora do Amiloide/biossíntese; Precursor de Proteína beta-Amiloide/biossíntese; Ácido Aspártico Endopeptidases/biossíntese; Proteínas de Ligação a DNA/metabolismo; Transtornos da Memória/metabolismo; NF-kappa B/metabolismo; Fatores de Transcrição/metabolismo; Transcrição Gênica; Doença de Alzheimer/genética; Doença de Alzheimer/patologia; Secretases da Proteína Precursora do Amiloide/genética; Precursor de Proteína beta-Amiloide/genética; Animais; Ácido Aspártico Endopeptidases/genética; Proteínas de Ligação a DNA/genética; Modelos Animais de Doenças; Humanos; Transtornos da Memória/genética; Transtornos da Memória/patologia; Camundongos; Camundongos Transgênicos; Fatores de Transcrição/genética

Palavras-chave

Alzheimer's disease; Amyloid precursor protein (APP); Bcl-2-associated athanogen 1 (BAG-1); NF-κB; ß-Site APP-cleaving enzyme 1 (BACE1)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Transcrição Gênica / Ácido Aspártico Endopeptidases / NF-kappa B / Precursor de Proteína beta-Amiloide / Proteínas de Ligação a DNA / Secretases da Proteína Precursora do Amiloide / Doença de Alzheimer / Transtornos da Memória Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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