TRPC Channel Structure and Properties.
Adv Exp Med Biol
; 976: 9-23, 2017.
Article
em En
| MEDLINE
| ID: mdl-28508309
TRPC channels are the first identified members in the TRP family. They function as either homo- or heterotetramers regulating intracellular Ca2+ concentration in response to numerous physiological or pathological stimuli. TRPC channels are nonselective cation channels permeable to Ca2+. The properties and the functional domains of TRPC channels have been identified by electrophysiological and biochemical methods. However, due to the large size, instability, and flexibility of their complexes, the structures of the members in TRPC family remain unrevealed. More efforts should be made on structure analysis and generating good tools, including specific antibodies, agonist, and antagonist.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cálcio
/
Canais de Cátion TRPC
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article