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RNA-seq analyses reveal that cervical spinal cords and anterior motor neurons from amyotrophic lateral sclerosis subjects show reduced expression of mitochondrial DNA-encoded respiratory genes, and rhTFAM may correct this respiratory deficiency.
Ladd, Amy C; Brohawn, David G; Thomas, Ravindar R; Keeney, Paula M; Berr, Stuart S; Khan, Shaharyar M; Portell, Francisco R; Shakenov, Meiram Zh; Antkowiak, Patrick F; Kundu, Bijoy; Tustison, Nicholas; Bennett, James P.
Afiliação
  • Ladd AC; Parkinson's Disease Research Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Brohawn DG; Parkinson's Disease Research Center, Virginia Commonwealth University, Richmond, VA, USA; Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA.
  • Thomas RR; Parkinson's Disease Research Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Keeney PM; Parkinson's Disease Research Center, Virginia Commonwealth University, Richmond, VA, USA; Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA; Neurodegeneration Therapeutics, Inc., Charlottesville, VA, USA.
  • Berr SS; Department of Radiology, University of Virginia, Charlottesville, VA, USA.
  • Khan SM; Gencia Corporation, LLC, Charlottesville, VA, USA.
  • Portell FR; Gencia Corporation, LLC, Charlottesville, VA, USA.
  • Shakenov MZ; Department of Science and Education, University Medical Center Corporate Fund, National Center for Children's Rehabilitation, Astana, Kazakhstan.
  • Antkowiak PF; Department of Radiology, University of Virginia, Charlottesville, VA, USA.
  • Kundu B; Department of Radiology, University of Virginia, Charlottesville, VA, USA.
  • Tustison N; Department of Radiology, University of Virginia, Charlottesville, VA, USA.
  • Bennett JP; Parkinson's Disease Research Center, Virginia Commonwealth University, Richmond, VA, USA; Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA; Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA; Neurodegeneration Therapeutics, Inc.,
Brain Res ; 1667: 74-83, 2017 07 15.
Article em En | MEDLINE | ID: mdl-28511992
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Mitocondriais / Proteínas de Ligação a DNA / Medula Cervical / Esclerose Lateral Amiotrófica / Neurônios Motores Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Mitocondriais / Proteínas de Ligação a DNA / Medula Cervical / Esclerose Lateral Amiotrófica / Neurônios Motores Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article