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12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents.
Nicolaou, K C; Rhoades, Derek; Wang, Yanping; Bai, Ruoli; Hamel, Ernest; Aujay, Monette; Sandoval, Joseph; Gavrilyuk, Julia.
Afiliação
  • Nicolaou KC; Department of Chemistry, BioScience Research Collaborative, Rice University , 6100 Main Street, Houston, Texas 77005, United States.
  • Rhoades D; Department of Chemistry, BioScience Research Collaborative, Rice University , 6100 Main Street, Houston, Texas 77005, United States.
  • Wang Y; Department of Chemistry, BioScience Research Collaborative, Rice University , 6100 Main Street, Houston, Texas 77005, United States.
  • Bai R; Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health , Frederick, Maryland 21702, United States.
  • Hamel E; Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health , Frederick, Maryland 21702, United States.
  • Aujay M; Abbvie Stemcentrx, LLC , 450 East Jamie Court, South San Francisco, California 94080, United States.
  • Sandoval J; Abbvie Stemcentrx, LLC , 450 East Jamie Court, South San Francisco, California 94080, United States.
  • Gavrilyuk J; Abbvie Stemcentrx, LLC , 450 East Jamie Court, South San Francisco, California 94080, United States.
J Am Chem Soc ; 139(21): 7318-7334, 2017 05 31.
Article em En | MEDLINE | ID: mdl-28513142
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aziridinas / Desenho de Fármacos / Epotilonas / Alcenos / Organofosfonatos / Cetonas / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aziridinas / Desenho de Fármacos / Epotilonas / Alcenos / Organofosfonatos / Cetonas / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article