Decreased expression of leukotriene B4 receptor sites on polymorphonuclear granulocytes of severely burned patients.
Prostaglandins Leukot Essent Fatty Acids
; 34(3): 153-9, 1988 Dec.
Article
em En
| MEDLINE
| ID: mdl-2851837
ABSTRACT
Polymorphonuclear granulocytes were isolated from patients with burn injury and the specific binding of (3H)leukotriene B4 was assessed. We observed a decreased receptor expression as compared to healthy donor cells, which may be the result of receptor downregulation as a consequence of cellular preactivation. In addition, leukotriene B4-synthesis was also reduced and differential cell counts demonstrated a shift from segmented neutrophils to immature cells. In survivors the values returned to normal parameters whereas nonsurvivors who succumbed in the course of generalized sepsis showed depressed cellular functions up to their death.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Queimaduras
/
Receptores Imunológicos
/
Granulócitos
Limite:
Humans
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article