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Factors associated with a poor prognosis for the IVF-ICSI live birth rate in women with rAFS stage III and IV endometriosis.
Roux, Pauline; Perrin, Jeanne; Mancini, Julien; Agostini, Aubert; Boubli, Léon; Courbiere, Blandine.
Afiliação
  • Roux P; Department of Women, Parents and Children, Clinico-Biological Center for Assisted Reproductive Technology - CECOS, AP-HM La Conception, 147 bd Baille, 13005, Marseille, France. paulyne003@gmail.com.
  • Perrin J; Department of Women, Parents and Children, Clinico-Biological Center for Assisted Reproductive Technology - CECOS, AP-HM La Conception, 147 bd Baille, 13005, Marseille, France.
  • Mancini J; Aix-Marseille Université, CNRS, IRD, |, Avignon Université, IMBE UMR 7263, 13397, Marseille, France.
  • Agostini A; Department of Biostatistics, AP-HM, Hôpital de la Timone, BiosTIC, 264 rue Saint-Pierre, 13385, Marseille, France.
  • Boubli L; Aix Marseille Université, INSERM, IRD, UMR912 SESSTIM, Marseille, France.
  • Courbiere B; Department of Women, Parents and Children, Clinico-Biological Center for Assisted Reproductive Technology - CECOS, AP-HM La Conception, 147 bd Baille, 13005, Marseille, France.
J Assist Reprod Genet ; 34(7): 921-928, 2017 Jul.
Article em En | MEDLINE | ID: mdl-28523409
PURPOSE: To assess the factors associated with a poor prognosis for a cumulative IVF live birth rate (LBR) in women with stage III and IV endometriosis according to the revised classification of the American Fertility Society (rAFS). METHODS: A retrospective cohort study was conducted between January 1, 2010, and December 31, 2014, in our Reproductive Medicine Center. We analyzed different factors associated with a poor prognosis for a cumulative IVF LBR in women with rAFS stage III and IV endometriosis. A total of 101 patients were included, representing 232 IVF-ICSI cycles and 212 embryo transfers. The primary endpoint was the cumulative LBR per cycle and per patient. RESULTS: The cumulative LBR per cycle was 14.7% (n = 34) and that per patient was 31.7% (n = 32). The cumulative LBR was significantly decreased by active smoking [adjOR = 3.4, 95% CI (1.12-10.60), p = 0.031], poor ovarian response (POR) according to the Bologna criteria [adjOR = 11.5, 95% CI (1.37-96.83), p = 0.024], and rAFS stage IV [adjOR = 3.2, 95% CI (1.13-8.95), p = 0.024]. The cumulative LBR per women was 59.4% without factors associated with a poor prognosis and 25.6% in the case of one factor, and it decreased to 7.7% in the case of two or three factors (p < 0.001). CONCLUSION: Active smoking, POR according to the Bologna criteria, and rAFS stage IV endometriosis had a negative impact on the IVF-ICSI cumulative LBR for women with rAFS stage III and IV endometriosis. Because smoking dramatically decreases the LBR with endometriosis, stopping smoking before IVF-ICSI should be strongly advised.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Injeções de Esperma Intracitoplásmicas / Endometriose / Infertilidade Feminina Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Injeções de Esperma Intracitoplásmicas / Endometriose / Infertilidade Feminina Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2017 Tipo de documento: Article