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Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.
Lowell, Andrew N; DeMars, Matthew D; Slocum, Samuel T; Yu, Fengan; Anand, Krithika; Chemler, Joseph A; Korakavi, Nisha; Priessnitz, Jennifer K; Park, Sung Ryeol; Koch, Aaron A; Schultz, Pamela J; Sherman, David H.
Afiliação
  • Lowell AN; Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • DeMars MD; Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Slocum ST; Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Yu F; Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Anand K; Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Chemler JA; Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Korakavi N; Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Priessnitz JK; Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Park SR; Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Koch AA; Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Schultz PJ; Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.
  • Sherman DH; Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.
J Am Chem Soc ; 139(23): 7913-7920, 2017 06 14.
Article em En | MEDLINE | ID: mdl-28525276
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tilosina / Macrolídeos / Policetídeo Sintases / Policetídeos / Antibacterianos Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tilosina / Macrolídeos / Policetídeo Sintases / Policetídeos / Antibacterianos Idioma: En Ano de publicação: 2017 Tipo de documento: Article