Perspectives on Gene Regulatory Network Evolution.
Trends Genet
; 33(7): 436-447, 2017 07.
Article
em En
| MEDLINE
| ID: mdl-28528721
ABSTRACT
Animal development proceeds through the activity of genes and their cis-regulatory modules (CRMs) working together in sets of gene regulatory networks (GRNs). The emergence of species-specific traits and novel structures results from evolutionary changes in GRNs. Recent work in a wide variety of animal models, and particularly in insects, has started to reveal the modes and mechanisms of GRN evolution. I discuss here various aspects of GRN evolution and argue that developmental system drift (DSD), in which conserved phenotype is nevertheless a result of changed genetic interactions, should regularly be viewed from the perspective of GRN evolution. Advances in methods to discover related CRMs in diverse insect species, a critical requirement for detailed GRN characterization, are also described.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Redes Reguladoras de Genes
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article