Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia.

Wang, Chunxue; Pallan, Pradeep S; Zhang, Wei; Lei, Li; Yoshimoto, Francis K; Waterman, Michael R; Egli, Martin; Guengerich, F Peter

Wang, Chunxue; Pallan, Pradeep S; Zhang, Wei; Lei, Li; Yoshimoto, Francis K; Waterman, Michael R; Egli, Martin; Guengerich, F Peter.

Afiliação

Wang C; From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
Pallan PS; From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
Zhang W; From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
Lei L; From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
Yoshimoto FK; From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
Waterman MR; From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
Egli M; From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146 martin.egli@vanderbilt.edu.
Guengerich FP; From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146 f.guengerich@vanderbilt.edu.

J Biol Chem ; 292(26): 10767-10778, 2017 06 30.

Article em En | MEDLINE | ID: mdl-28539365

Assuntos

Hiperplasia Suprarrenal Congênita/enzimologia; Mutação; Esteroide 21-Hidroxilase/química; Hiperplasia Suprarrenal Congênita/genética; Dicroísmo Circular; Citocromos b5/química; Citocromos b5/genética; Citocromos b5/metabolismo; Medição da Troca de Deutério; Estabilidade Enzimática; Temperatura Alta; Humanos; Domínios Proteicos; Espectrofotometria Ultravioleta; Esteroide 21-Hidroxilase/genética; Esteroide 21-Hidroxilase/metabolismo

Palavras-chave

X-ray crystallography; circular dichroism (CD); congenital adrenal hyperplasia; cytochrome P450; isotope effect; steroid; steroid biosynthesis; steroid hormone

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esteroide 21-Hidroxilase / Hiperplasia Suprarrenal Congênita / Mutação Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google