Targeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase.

Yamazaki, Taiga; Hatano, Yu; Handa, Tetsuya; Kato, Sakiko; Hoida, Kensuke; Yamamura, Rui; Fukuyama, Takashi; Uematsu, Takayuki; Kobayashi, Noritada; Kimura, Hiroshi; Yamagata, Kazuo

Yamazaki, Taiga; Hatano, Yu; Handa, Tetsuya; Kato, Sakiko; Hoida, Kensuke; Yamamura, Rui; Fukuyama, Takashi; Uematsu, Takayuki; Kobayashi, Noritada; Kimura, Hiroshi; Yamagata, Kazuo.

Afiliação

Yamazaki T; Division of Biomedical Research, Kitasato University Medical Center, Kitasato University, Kitamoto, Saitama, Japan.
Hatano Y; Faculty of Biology-Oriented Science and Technology, KINDAI University, Kinokawa, Wakayama, Japan.
Handa T; Cell Biology Unit, Institute of Innovative Research, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.
Kato S; Faculty of Biology-Oriented Science and Technology, KINDAI University, Kinokawa, Wakayama, Japan.
Hoida K; Faculty of Biology-Oriented Science and Technology, KINDAI University, Kinokawa, Wakayama, Japan.
Yamamura R; Division of Biomedical Research, Kitasato University Medical Center, Kitasato University, Kitamoto, Saitama, Japan.
Fukuyama T; Division of Biomedical Research, Kitasato University Medical Center, Kitasato University, Kitamoto, Saitama, Japan.
Uematsu T; Division of Biomedical Research, Kitasato University Medical Center, Kitasato University, Kitamoto, Saitama, Japan.
Kobayashi N; Division of Biomedical Research, Kitasato University Medical Center, Kitasato University, Kitamoto, Saitama, Japan.
Kimura H; Cell Biology Unit, Institute of Innovative Research, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.
Yamagata K; Faculty of Biology-Oriented Science and Technology, KINDAI University, Kinokawa, Wakayama, Japan.

PLoS One ; 12(5): e0177764, 2017.

Article em En | MEDLINE | ID: mdl-28542388

Assuntos

Centrômero/genética; DNA (Citosina-5-)-Metiltransferases/metabolismo; Metilação de DNA/genética; Edição de Genes/métodos; Genômica; Animais; Sequência de Bases; Linhagem Celular; Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas/genética; DNA Satélite/genética; Implantação do Embrião; Camundongos; Regulação para Cima/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Centrômero / Metilação de DNA / Genômica / DNA (Citosina-5-)-Metiltransferases / Edição de Genes Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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