Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease.
Dev Med Child Neurol
; 59(9): 894-902, 2017 09.
Article
em En
| MEDLINE
| ID: mdl-28542743
ABSTRACT
This review integrates data on brain dysmaturation and acquired brain injury using fetal and neonatal magnetic resonance imaging (MRI), including the contribution of cardiovascular physiology to differences in brain development, and the relationship between brain abnormalities and subsequent neurological impairments in infants with congenital heart disease (CHD). The antenatal and neonatal period are critical for optimal brain development; the developing brain is particularly vulnerable to haemodynamic disturbances during this time. Altered cerebral perfusion and decreased cerebral oxygen delivery in the antenatal period can affect functional and structural brain development, while postnatal haemodynamic fluctuations may cause additional injury. In critical CHD, brain dysmaturation and acquired brain injury result from a combination of underlying cardiovascular pathology and surgery performed in the neonatal period. MRI findings in infants with CHD can be used to evaluate potential clinical risk factors for brain abnormalities, and aid prediction of functional outcomes at an early stage. In addition, information on timing of brain dysmaturation and acquired brain injury in CHD has the potential to be used when developing strategies to optimize neurodevelopment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Sistema Cardiovascular
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Cardiopatias Congênitas
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Humans
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Infant
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article