Mild cognitive impairment and structural brain abnormalities in a sexagenarian with a history of childhood traumatic brain injury.
J Neurosci Res
; 96(4): 652-660, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-28543689
ABSTRACT
In this report, we present a case study involving an older, female patient with a history of pediatric traumatic brain injury (TBI). Magnetic resonance imaging and diffusion tensor imaging volumes were acquired from the volunteer in question, her brain volumetrics and morphometrics were extracted, and these were then systematically compared against corresponding metrics obtained from a large sample of older healthy control (HC) subjects as well as from subjects in various stages of mild cognitive impairment (MCI) and Alzheimer disease (AD). Our analyses find the patient's brain morphometry and connectivity most similar to those of patients classified as having early-onset MCI, in contrast to HC, late MCI, and AD samples. Our examination will be of particular interest to those interested in assessing the clinical course in older patients having suffered TBI earlier in life, in contradistinction to those who experience incidents of head injury during aging.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Disfunção Cognitiva
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Lesões Encefálicas Traumáticas
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Aged
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Child
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Female
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article