Human Y-chromosome variation in the genome-sequencing era.
Nat Rev Genet
; 18(8): 485-497, 2017 08.
Article
em En
| MEDLINE
| ID: mdl-28555659
ABSTRACT
The properties of the human Y chromosome - namely, male specificity, haploidy and escape from crossing over - make it an unusual component of the genome, and have led to its genetic variation becoming a key part of studies of human evolution, population history, genealogy, forensics and male medical genetics. Next-generation sequencing (NGS) technologies have driven recent progress in these areas. In particular, NGS has yielded direct estimates of mutation rates, and an unbiased and calibrated molecular phylogeny that has unprecedented detail. Moreover, the availability of direct-to-consumer NGS services is fuelling a rise of 'citizen scientists', whose interest in resequencing their own Y chromosomes is generating a wealth of new data.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo de Nucleotídeo Único
/
Cromossomos Humanos Y
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article