Enantioselective Reaction of 2H-Azirines with Phosphite Using Chiral Bis(imidazoline)/Zinc(II) Catalysts.
Angew Chem Int Ed Engl
; 56(30): 8785-8789, 2017 07 17.
Article
em En
| MEDLINE
| ID: mdl-28557241
The first highly enantioselective nucleophilic addition reaction of phosphites with 2H-azirines has been developed. The reaction was applied to various 3-substituted 2H-azirines using novel chiral bis(imidazoline)/ZnII catalysts to afford products in good yield with high enantioselectivity. The transformation of the obtained optically active aziridines showed that 2H-azirines act as either α,ß- or ß,ß-dicarbocationic amine synthons.
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01-internacional
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MEDLINE
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En
Ano de publicação:
2017
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Article