Understanding Rate Acceleration and Stereoinduction of an Asymmetric Giese Reaction Mediated by a Chiral Rhodium Catalyst.
J Am Chem Soc
; 139(24): 8062-8065, 2017 06 21.
Article
em En
| MEDLINE
| ID: mdl-28558465
ABSTRACT
The surprising acceleration of the addition of electron-rich radicals to α,ß-unsaturated 2-acyl imidazoles by a chiral-at-metal rhodium catalyst is investigated. M06/Lanl2DZ (Rh),6-31G(d) calculations reproduce the observed rate acceleration and shed light on a catalyst design where a rigid chiral pocket with a steric interaction >5 Å from the chiral metal center leads to the observed high stereoinduction. Analysis of the molecular orbitals of two key addition transition states emphasize the role of the catalyst as a Lewis acid without significant charge transfer.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2017
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Article