Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma.
Oncogene
; 3(5): 537-40, 1988 Nov.
Article
em En
| MEDLINE
| ID: mdl-2856253
ABSTRACT
Transforming activity was detected in a hepatocellular carcinoma (HCC) carrying four integrated hepatitis B virus (HBV) DNA. This transforming gene was identified as hst-1, that lies in chromosome 11, band q13.3. One of the integrated HBV DNAs was found to lie close to the hst-1, and the hst-1 and the integrated HBV DNA were found to be co-amplified. The region of the amplification was limited. A model has been proposed that correlates the viral integration, amplification and activation of an oncogene.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oncogenes
/
Cromossomos Humanos Par 11
/
DNA Viral
/
Transformação Celular Neoplásica
/
Amplificação de Genes
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Vírus da Hepatite B
/
Carcinoma Hepatocelular
/
Genes Virais
/
Neoplasias Hepáticas
Limite:
Humans
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article