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Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
Helal, Christopher J; Arnold, Eric P; Boyden, Tracey L; Chang, Cheng; Chappie, Thomas A; Fennell, Kimberly F; Forman, Michael D; Hajos, Mihaly; Harms, John F; Hoffman, William E; Humphrey, John M; Kang, Zhijun; Kleiman, Robin J; Kormos, Bethany L; Lee, Che-Wah; Lu, Jiemin; Maklad, Noha; McDowell, Laura; Mente, Scot; O'Connor, Rebecca E; Pandit, Jayvardhan; Piotrowski, Mary; Schmidt, Anne W; Schmidt, Christopher J; Ueno, Hirokazu; Verhoest, Patrick R; Yang, Edward X.
Afiliação
  • Helal CJ; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Arnold EP; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Boyden TL; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Chang C; Pfizer Worldwide Research and Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Chappie TA; Pfizer Worldwide Research and Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Fennell KF; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Forman MD; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Hajos M; Pfizer Worldwide Research and Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Harms JF; Pfizer Worldwide Research and Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Hoffman WE; Pfizer Worldwide Research and Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Humphrey JM; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Kang Z; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Kleiman RJ; Pfizer Worldwide Research and Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Kormos BL; Pfizer Worldwide Research and Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Lee CW; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Lu J; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Maklad N; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • McDowell L; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Mente S; Pfizer Worldwide Research and Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • O'Connor RE; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Pandit J; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Piotrowski M; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Schmidt AW; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Schmidt CJ; Pfizer Worldwide Research and Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Ueno H; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Verhoest PR; Pfizer Worldwide Research and Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.
  • Yang EX; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
J Med Chem ; 60(13): 5673-5698, 2017 07 13.
Article em En | MEDLINE | ID: mdl-28574706
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Desenho de Fármacos / Nucleotídeo Cíclico Fosfodiesterase do Tipo 2 Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Desenho de Fármacos / Nucleotídeo Cíclico Fosfodiesterase do Tipo 2 Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article