FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis.
Mol Metab
; 6(6): 471-481, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-28580278
Palavras-chave
ACC; ACC DKI, ACC1-S79A and ACC2-S212A double knock-in; ACC, acetyl-CoA carboxylase; AKT, protein kinase B; AMPK; AMPK, AMP-activated protein kinase; Adipocyte; BAT, brown adipose tissue; Brown fat; CNS, central nervous system; COX, cytochrome c oxidase; CreERT2, Cre recombinase estrogen receptor T2; DAG, diacylglycerol; Diabetes; FFA, free fatty acid; FGF21; FGF21, fibroblast growth factor 21; FGFR1c, fibroblast growth factor receptor 1c; GTT, glucose tolerance test; H&E, hematoxylin and eosin; HFD, high fat diet; ITT, insulin tolerance test; KLB, beta klotho; NAFLD, non-alcoholic fatty liver disease; Obesity; RER, respiratory exchange ratio; TAG, triacylglycerol; UCP1, uncoupling protein 1; WAT, white adipose tissue; WT, wildtype; gWAT, gonadal white adipose tissue; iWAT, inguinal white adipose tissue; iß1ß2AKO, inducible AMPK ß1ß2 adipocyte knockout; mTORC1, mammalian target of rapamycin
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acetil-CoA Carboxilase
/
Proteínas Quinases
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Fatores de Crescimento de Fibroblastos
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Glucose
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article