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Perturbations in the Replication Program Contribute to Genomic Instability in Cancer.
Blumenfeld, Britny; Ben-Zimra, Micha; Simon, Itamar.
Afiliação
  • Blumenfeld B; Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel. britny.blumenfeld@mail.huji.ac.il.
  • Ben-Zimra M; Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel. micha.ben-zimra@mail.huji.ac.il.
  • Simon I; Pharmacology and Experimental Therapeutics Unit, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. micha.ben-zimra@mail.huji.ac.il.
Int J Mol Sci ; 18(6)2017 May 25.
Article em En | MEDLINE | ID: mdl-28587102
ABSTRACT
Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Instabilidade Genômica / Replicação do DNA / Mutação / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Instabilidade Genômica / Replicação do DNA / Mutação / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article