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Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters.
Vong, Kenward K H; Tsubokura, Kazuki; Nakao, Yoichi; Tanei, Tomonori; Noguchi, Shinzaburo; Kitazume, Shinobu; Taniguchi, Naoyuki; Tanaka, Katsunori.
Afiliação
  • Vong KKH; Biofunctional Synthetic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan. kotzenori@riken.jp.
  • Tsubokura K; Biofunctional Synthetic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan. kotzenori@riken.jp and School of Advanced Science and Engineering, Department of Chemistry and Biochemistry, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan.
  • Nakao Y; School of Advanced Science and Engineering, Department of Chemistry and Biochemistry, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan.
  • Tanei T; Department of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, 2-2-E10 Yamadaoka, Suita-shi, Osaka, 565-0871, Japan.
  • Noguchi S; Department of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, 2-2-E10 Yamadaoka, Suita-shi, Osaka, 565-0871, Japan.
  • Kitazume S; Disease Glycomics Team, Global Research Cluster, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
  • Taniguchi N; Disease Glycomics Team, Global Research Cluster, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
  • Tanaka K; Biofunctional Synthetic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan. kotzenori@riken.jp and Biofunctional Chemistry Laboratory, A. Butlerov Institute of Chemistry, Kazan Federal University, 18 Kremlyovskaya Street, Kazan, 420008, Russia and JST, PRESTO, 2-1 Hirosawa
Chem Commun (Camb) ; 53(60): 8403-8406, 2017 Jul 25.
Article em En | MEDLINE | ID: mdl-28589196
Rapidly growing cancer cells have increased levels of intracellular polyamines compared to normal, healthy tissues. Based on the selective reactivity of glycine propargyl esters, probes were synthesized that show evidence for selective polyamine reactivity, which was then applied for selective cancer cell imaging studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article