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Efficacy of chemotherapy in extremely elderly patients with diffuse large B-cell lymphoma.
Takahashi, Anna; Mishima, Yuko; Yokoyama, Masahiro; Inoue, Norihito; Kusano, Yoshiharu; Gunji, Tadahiro; Nitta, Hideaki; Ueda, Kyoko; Nishimura, Noriko; Tsuyama, Naoko; Takeuchi, Kengo; Terui, Yasuhito; Hatake, Kiyohiko.
Afiliação
  • Takahashi A; Dept. of Hematology and Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research.
  • Mishima Y; Dept. of Hematology and Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research.
  • Yokoyama M; Dept. of Hematology and Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research.
  • Inoue N; Dept. of Hematology and Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research.
  • Kusano Y; Dept. of Hematology and Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research.
  • Gunji T; Dept. of Hematology and Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research.
  • Nitta H; Dept. of Hematology and Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research.
  • Ueda K; Dept. of Hematology and Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research.
  • Nishimura N; Dept. of Hematology and Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research.
  • Tsuyama N; Dept. of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research.
  • Takeuchi K; Dept. of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research.
  • Terui Y; Pathology Project for Molecular Targets, The Cancer Institute, Japanese Foundation for Cancer Research.
  • Hatake K; Dept. of Hematology and Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research.
Rinsho Ketsueki ; 58(5): 427-432, 2017.
Article em Ja | MEDLINE | ID: mdl-28592754
ABSTRACT
The safety and effective dose of chemotherapy in treating non-Hodgkin lymphoma in elderly patients is yet to be established. In this study, we assessed the prognosis of diffuse large B-cell lymphoma (DLBCL) in elderly patients (≥75 years) treated with an optimal dose of R-CHOP. No significant differences were observed in progression-free survival between elderly patients and patients aged <74 years with DLBCL. Furthermore, no differences were observed between full-dose R-CHOP and 80% dose R-CHOP groups. Median relative dose intensity was 0.80 in elderly patients with DLBCL. Thus, our data suggested that 80% dose R-CHOP is tolerable and effective in these patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Linfoma Difuso de Grandes Células B Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: Ja Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Linfoma Difuso de Grandes Células B Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: Ja Ano de publicação: 2017 Tipo de documento: Article