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Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy.
Huang, Tzu-Ting; Su, Jung-Chen; Liu, Chun-Yu; Shiau, Chung-Wai; Chen, Kuen-Feng.
Afiliação
  • Huang TT; Comprehensive Breast Health Center, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan. abby-eve@hotmail.com.
  • Su JC; Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan. abby-eve@hotmail.com.
  • Liu CY; Institute of Biopharmaceutical Sciences, National Yang-Ming University, No. 155, Sec. 2, Li-Nong Street, Taipei 112, Taiwan. jjjaannee@hotmail.com.
  • Shiau CW; Faculty of Pharmacy, National Yang-Ming University, No. 155, Sec. 2, Li-Nong Street, Taipei 112, Taiwan. jjjaannee@hotmail.com.
  • Chen KF; Comprehensive Breast Health Center, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan. cyliu3@gmail.com.
Int J Mol Sci ; 18(6)2017 Jun 08.
Article em En | MEDLINE | ID: mdl-28594363
The Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 1 (SHP-1), a non-receptor protein tyrosine phosphatase, has been reported as a negative regulator of phosphorylated signal transducer and activator of transcription 3 (STAT3) and linked to tumor development. In this present review, we will discuss the importance and function of SHP-1/p-STAT3 signaling in nonmalignant conditions as well as malignancies, its cross-talk with other pathways, the current clinical development and the potential role of inhibitors of this pathway in anticancer therapy and clinical relevance of SHP-1/p-STAT3 in cancers. Lastly, we will summarize and highlight work involving novel drugs/compounds targeting SHP-1/p-STAT3 signaling and combined strategies that were/are discovered in our and our colleagues' laboratories.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Fator de Transcrição STAT3 / Proteína Tirosina Fosfatase não Receptora Tipo 6 / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Fator de Transcrição STAT3 / Proteína Tirosina Fosfatase não Receptora Tipo 6 / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article