Transcriptional Changes in the Mouse Retina after Ocular Blast Injury: A Role for the Immune System.
J Neurotrauma
; 35(1): 118-129, 2018 01 01.
Article
em En
| MEDLINE
| ID: mdl-28599600
ABSTRACT
Ocular blast injury is a major medical concern for soldiers and explosion victims due to poor visual outcomes. To define the changes in gene expression following a blast injury to the eye, we examined retinal ribonucleic acid (RNA) expression in 54 mouse strains 5 days after a single 50-psi overpressure air wave blast injury. We observe that almost 40% of genes are differentially expressed with a false discovery rate (FDR) of <0.001, even though the nominal changes in RNA expression are rather small. Moreover, we find through machine learning approaches that genetic networks related to the innate and acquired immune system are activated. Accompanied by lymphocyte invasion into the inner retina, blast injury also results in progressive loss of visual function and retinal ganglion cells (RGCs). Collectively, these data demonstrate how systems genetics can be used to put meaning to the transcriptome changes following ocular blast injury that eventually lead to blindness.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
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Transcrição Gênica
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Traumatismos por Explosões
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Traumatismos Oculares
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article