Novel pyridyl nitrofuranyl isoxazolines show antibacterial activity against multiple drug resistant Staphylococcus species.

Picconi, Pietro; Prabaharan, Priya; Auer, Jennifer L; Sandiford, Stephanie; Cascio, Francesco; Chowdhury, Madiha; Hind, Charlotte; Wand, Matthew E; Sutton, J Mark; Rahman, Khondaker M

Picconi, Pietro; Prabaharan, Priya; Auer, Jennifer L; Sandiford, Stephanie; Cascio, Francesco; Chowdhury, Madiha; Hind, Charlotte; Wand, Matthew E; Sutton, J Mark; Rahman, Khondaker M.

Afiliação

Picconi P; Institute of Pharmaceutical Science, King's College London, London SE1 1DB, UK.
Prabaharan P; Institute of Pharmaceutical Science, King's College London, London SE1 1DB, UK.
Auer JL; Institute of Pharmaceutical Science, King's College London, London SE1 1DB, UK.
Sandiford S; Public Health England, National Infections Service, Porton Down, Salisbury SP4 0JG, Wiltshire, UK.
Cascio F; Institute of Pharmaceutical Science, King's College London, London SE1 1DB, UK.
Chowdhury M; Institute of Pharmaceutical Science, King's College London, London SE1 1DB, UK.
Hind C; Public Health England, National Infections Service, Porton Down, Salisbury SP4 0JG, Wiltshire, UK.
Wand ME; Public Health England, National Infections Service, Porton Down, Salisbury SP4 0JG, Wiltshire, UK.
Sutton JM; Public Health England, National Infections Service, Porton Down, Salisbury SP4 0JG, Wiltshire, UK. Electronic address: mark.sutton@phe.gov.uk.
Rahman KM; Institute of Pharmaceutical Science, King's College London, London SE1 1DB, UK. Electronic address: k.miraz.rahman@kcl.ac.uk.

Bioorg Med Chem ; 25(15): 3971-3979, 2017 08 01.

Article em En | MEDLINE | ID: mdl-28600080

Assuntos

Antibacterianos/farmacologia; Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos; Nitrofurantoína/química; Oxazóis/farmacologia; Staphylococcus aureus/efeitos dos fármacos; Antibacterianos/química; Linhagem Celular Tumoral; Humanos; Testes de Sensibilidade Microbiana; Oxazóis/química; Análise Espectral; Relação Estrutura-Atividade

Palavras-chave

Antibacterial activity; Antimicrobial resistance; MRSA; Medicinal chemistry; Nitrofuran isoxazoline; Structure activity relationship

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxazóis / Staphylococcus aureus / Farmacorresistência Bacteriana Múltipla / Antibacterianos / Nitrofurantoína Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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