[Sirt1 inhibited oxidized low-density lipoprotein induced smooth muscle cells inflammatory response].

ABSTRACT

Objective: To investigate the mechanism of inflammation of smooth muscle cells induced by oxidized low-density lipoprotein through Sirt1 in the atherosclerosis. Methods: The expression of Sirt1 had been measured in the plaque tissues of human and mice. The affection of overexpression of SIRT1 on the oxLDL induced-inflammatory response and ROS generation had been detected in this study. Results: Sirt1 decreased in smooth muscle cells region of human plaque. And in the smooth muscle cells region of mice plaque, Sirt1 was also significantly decreased about 5-fold (P<0.05). Although, oxLDL promoted inflammatory cytokines secretion and ROS generation, but this affection had been reversed by upregulating Sirt1. Conclusion: oxLDL regulated smooth muscle cells inflammatory response via Sirt1. Thus, Sirt1 is a signaling molecular regulating smooth muscles inflammatory response in the process of atherosclerosis.