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Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development.
Harbeson, Scott L; Morgan, Adam J; Liu, Julie F; Aslanian, Ara M; Nguyen, Sophia; Bridson, Gary W; Brummel, Christopher L; Wu, Lijun; Tung, Roger D; Pilja, Lana; Braman, Virginia; Uttamsingh, Vinita.
Afiliação
  • Harbeson SL; Concert Pharmaceuticals, Inc., Lexington, Massachusetts sharbeson@concertpharma.com.
  • Morgan AJ; Concert Pharmaceuticals, Inc., Lexington, Massachusetts.
  • Liu JF; Concert Pharmaceuticals, Inc., Lexington, Massachusetts.
  • Aslanian AM; Concert Pharmaceuticals, Inc., Lexington, Massachusetts.
  • Nguyen S; Concert Pharmaceuticals, Inc., Lexington, Massachusetts.
  • Bridson GW; Concert Pharmaceuticals, Inc., Lexington, Massachusetts.
  • Brummel CL; Concert Pharmaceuticals, Inc., Lexington, Massachusetts.
  • Wu L; Concert Pharmaceuticals, Inc., Lexington, Massachusetts.
  • Tung RD; Concert Pharmaceuticals, Inc., Lexington, Massachusetts.
  • Pilja L; Concert Pharmaceuticals, Inc., Lexington, Massachusetts.
  • Braman V; Concert Pharmaceuticals, Inc., Lexington, Massachusetts.
  • Uttamsingh V; Concert Pharmaceuticals, Inc., Lexington, Massachusetts.
J Pharmacol Exp Ther ; 362(2): 359-367, 2017 08.
Article em En | MEDLINE | ID: mdl-28611092
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolonas / Deutério / Metaboloma / Aminofenóis Tipo de estudo: Clinical_trials Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolonas / Deutério / Metaboloma / Aminofenóis Tipo de estudo: Clinical_trials Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article