Correlation of MDR1 gene polymorphisms with anesthetic effect of sevoflurane-remifentanil following pediatric tonsillectomy.
Medicine (Baltimore)
; 96(24): e7002, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28614221
ABSTRACT
BACKGROUND:
The motive of this study was to investigate the collaboration between MDR1 gene polymorphisms and anesthetic effects following pediatric tonsillectomy.METHODS:
All together 178 children undergoing tonsillectomy with preoperative sevoflurane-remifentanil anesthesia were selected. In order to determine MDR1 gene polymorphisms of 3435Câ>âT, 1236Câ>âT, and 2677Gâ>âT/A, polymerase chain reaction-restriction fragment length polymorphism was used. Mean arterial pressure (MAP), diastolic blood pressure (DBP), systolic blood pressure (SBP), and heart rate (HR) at T0 (5 mins after the repose), T1 (0âmin after tracheal intubation), T2 (5 mins after the tracheal intubation), T3 (0âmin after the tonsillectomy), T4 (0âmin after removal of the mouth-gag) and T5 (5âmin after the extubation) were observed. The visual analog scale (VAS), the face, legs, activity, cry, and consolability (FLACC) pain assessment, and Ramsay sedation score were recorded after the patients gained consciousness. The adverse reactions were also observed.RESULTS:
As compared to the CTâ+âTT genotype of MDR1 1236Câ>âT, the time of induction, respiration recovery, eye-opening, and extubation of children with the CC genotype was found to be shorter (all Pâ<.05); the MAP, SBP, DBP, and HR were significantly reduced at T5 in children that possessed the CC genotype (all Pâ<.05), the VAS at postoperative 1, 2, 4, and 8âhours and Ramsay sedation score were decreased, while the FLACC score increased (all Pâ<.05). It was found that the adverse reaction rate was lower in children bearing the CC genotype (Pâ<.05).CONCLUSION:
It could be concluded that anesthetic effect in patients with the MDR1 1236Câ>âT CC genotype was found to be superior to those carrying the CTâ+âTT genotype.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Variantes Farmacogenômicos
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Anestésicos
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Éteres Metílicos
Limite:
Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article