The elevation of plasma concentrations of apoB-48-containing lipoproteins in familial hypercholesterolemia is independent of PCSK9 levels.
Lipids Health Dis
; 16(1): 119, 2017 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-28619117
ABSTRACT
BACKGROUND:
Previous studies have reported high plasma concentrations of both intestinal apolipoprotein (apo) B-48-containing lipoproteins and PCSK9 in subjects with familial hypercholesterolemia (FH). However, the extent to which LDL receptor deficiency and PCSK9 levels influence plasma apoB-48 concentrations in humans remains to be fully characterized. The objective of the study was to assess the independent association between FH, PCSK9 concentrations and plasma apoB-48 levels in a large cohort of genetically defined FH heterozygotes (HeFH) and homozygotes (HoFH).METHODS:
A total of 118 HeFH, 6 HoFH, and 117 controls were included in the study. Plasma PCSK9 and apoB-48 concentrations were measured in the fasting state.RESULTS:
Plasma PCSK9 and apoB-48 levels were higher in FH subjects compared with controls (PCSK9 HoFH 642.6 ± 246.9 vs. HeFH 324.9 ± 119.8 vs. CONTROLS 194.5 ± 65.9 ng/mL, P < 0.0001; apoB-48 HoFH 14.71 ± 4.36 vs. HeFH 6.55 ± 4.24 vs. CONTROLS 3.03 ± 2.07 µg/mL; P < 0.0001). There were no correlations between apoB-48 and PCSK9 plasma levels in both controls (ρ = 0.06, P = 0.5) and HeFH subjects (ρ = 0.07, P = 0.4). Multiple linear regression analysis showed that the FH status was the only independent factor associated with apoB-48 levels, contributing to 28.7% of the variance (P < 0.0001).CONCLUSIONS:
These data indicate that the elevation in plasma apoB-48 levels associated with FH is independent of PCSK9 levels. TRIAL REGISTRATION NCT02225340 .Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aterosclerose
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Apolipoproteína B-48
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Pró-Proteína Convertase 9
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Hiperlipoproteinemia Tipo II
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article