Comparison of volumetric and functional parameters in simultaneous cardiac PET/MR: feasibility of volumetric assessment with residual activity from prior PET/CT.
Eur Radiol
; 27(12): 5146-5157, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-28631080
ABSTRACT
OBJECTIVE:
To compare cardiac left ventricular (LV) parameters in simultaneously acquired hybrid fluorine-18-fluorodeoxyglucose ([18F] FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) in patients with residual tracer activity of upstream PET/CT.METHODS:
Twenty-nine patients (23 men, age 58±17 years) underwent cardiac PET/MRI either directly after a non-cardiac PET/CT with homogenous cardiac [18F] FDG uptake (n=20) or for viability assessment (n=9). Gated cardiac [18F] FDG PET and cine MR sequences were acquired simultaneously and evaluated blinded to the cross-imaging results. Image quality (IQ), end-diastolic (LVEDV), end-systolic volume (LVESV), ejection fraction (LVEF) and myocardial mass (LVMM) were measured. Pearson correlation and intraclass correlation coefficient (ICC), regression and a Bland-Altman analysis were assessed.RESULTS:
Except LVMM, volumetric and functional LV parameters demonstrated high correlations (LVESV r=0.97, LVEDV r=0.95, LVEF r=0.91, LVMM r=0.87, each p<0.05), but wide limits of agreement (LOA) for LVEDV (-25.3-82.5ml); LVESV (-33.1-72.7ml); LVEF (-18.9-14.8%) and LVMM (-78.2-43.2g). Intra- and interobserver reliability were very high (ICC≥0.95) for all parameters, except for MR-LVEF (ICC=0.87). PET-IQ (0-3) was high (mean 2.2±0.9) with significant influence on LVMM calculations only.CONCLUSION:
In simultaneously acquired cardiac PET/MRI data, LVEDV, LVESV and LVEF show good agreement. However, the agreement seems to be limited if cardiac PET/MRI follows PET/CT and only the residual activity is used. KEY POINTS ⢠[ 18 F] FDG PET-MRI is feasible with residual [ 18 F] FDG activity in patients with homogenous cardiac uptake. ⢠Cardiac volumes and function assessed by PET/MRI show good agreement. ⢠LVEDV and LVESV are underestimated; PET overestimates LVMM and LVEF. ⢠Cardiac PET and MRI data correlate better when acquired simultaneously than sequentially. ⢠PET and MRI should not assess LV parameters interchangeably.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Volume Sistólico
/
Doença da Artéria Coronariana
/
Imageamento por Ressonância Magnética
/
Função Ventricular Esquerda
/
Tomografia por Emissão de Pósitrons
/
Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
/
Ventrículos do Coração
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article