Regulation of Energy Homeostasis After Gastric Bypass Surgery.
Annu Rev Biomed Eng
; 19: 459-484, 2017 06 21.
Article
em En
| MEDLINE
| ID: mdl-28633561
ABSTRACT
The obesity epidemic continues to escalate each year in the United States more than anywhere else in the world. The existing pharmaceutical and other nonsurgical treatments for morbid obesity produce suboptimal physiologic outcomes compared with those of Roux-en-Y gastric bypass (RYGB) surgery. RYGB has been the gold standard of bariatric surgery because the beneficial long-term outcomes, which include sustainable weight loss and type 2 diabetes mellitus (T2DM) resolution, are far superior to those obtained with other bariatric surgeries. However, the current understanding of RYGB's mechanisms of actions remains limited and incomplete. There is an urgent need to understand these mechanisms as gaining this knowledge may lead to the development of innovative and less invasive procedures and/or medical devices, which can mirror the favorable outcomes of RYGB surgery. In this review, we highlight current observations of the metabolic and physiologic events following RYGB, with a particular focus on the role of the anatomical reconfiguration of the gastrointestinal tract after RYGB.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apetite
/
Estômago
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Derivação Gástrica
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Metabolismo Energético
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Percepção Gustatória
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Homeostase
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article